Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

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In FOOT REFRESH this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized.The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers.All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity.The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones.

In addition, complexes showed lower antimicrobial activity than the standard drugs, Me Fall Top similar to the activity of the starting thiosemicarbazones.